DNMT1-G9a-PCNA Complex Regulates DNA Methylation and Promotes Neurogenesis

Target Name: DNMT1-G9a-PCNA complex

NCBI ID: P18454

Other Name(s): None

DNMT1-G9a-PCNA Complex Regulates DNA Methylation and Promotes Neurogenesis

The DNMT1-G9a-PCNA complex is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of DNA methylation, a process that plays a crucial role in the development and maintenance of cellular and tissue properties. The DNMT1 gene is often mutated in various diseases, including cancer, and the G9a variant has been shown to have neuroprotective effects. The PCNA protein is a known regulator of DNA methylation and has been shown to interact with the DNMT1 gene.

The DNMT1-G9a-PCNA complex functions as a regulatory unit for DNA methylation in various tissues. When DNA is methylated, the gene is protected from transcription and replication, which can lead to the regulation of gene expression and the development of various diseases. The DNMT1-G9a-PCNA complex is involved in the regulation of DNA methylation at the gene level, and has been shown to play a role in the development of various diseases, including cancer.

One of the key functions of the DNMT1-G9a-PCNA complex is its role in neuroprotection. The DNMT1 gene is often mutated in various neurological and psychiatric diseases, including cancer, and the G9a variant has been shown to have neuroprotective effects. The PCNA protein is a known regulator of DNA methylation and has been shown to interact with the DNMT1 gene. This suggests that the DNMT1-G9a-PCNA complex may play a role in neuroprotection by regulating DNA methylation and promoting neurogenesis.

The DNMT1-G9a-PCNA complex is also involved in the regulation of cellular and tissue homeostasis. The DNMT1 gene is often mutated in various diseases, including cancer, and the G9a variant has been shown to have regulatory functions. The PCNA protein is a known regulator of DNA methylation and has been shown to interact with

Protein Name: DNMT1-G9a-PCNA Complex

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